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Dr.S.Singaravadivel

Overview

Dr. S. Singaravadivel is an Assistant Professor at SSMIET in chemistry department. He is working as a faculty in SSMIET for the past 5 Years 6 Months. His research is mainly focused on development of probes for sensing biomoelcules, Heavy metal ions, anions and explosives.

Contact:  vesp1984@gmail.com    +91-9942698726

Education

  • PDF (Chemistry), Institute of Chemistry, Academia Sinica, Taipei, Taiwan, 2012-2013.
  • Ph.D (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2012.
  • M.Phil (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2007.
  • M.Sc (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2006.
  • B.Sc (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2004.

Research

Singaram’s area of research is broadly focused on development of Organic, Polymer and NIR probes for sensing biomolecules, Heavy metal ions, anions and explosives with their practical applications in real time and in-vivo and in-vitro Cell-imaging.

Phenothiazine based sensor for naked-eye detection and bioimaging of Hg (II) and F− ions

This work is mainly concentrated on the design and development of new phenothiazine-based fluorescent probes, which display a selective fluorescence response to mercury and fluoride ions, were described. The probe is the first example that facilitates the detection of Hg2+ at nanomolar concentrations.  The sensitivity of probe P-1 to Hg2+ and F was demonstrated in living cells, and cell toxicity assays revealed that probe P-1 can be used for selective imaging of Hg2+ and F in living cells.

A rhodamine based “turn-on” fluorescent probe for Pb (ii) and live cell imaging

This work is mainly focused on a novel “turn-on” fluorescent chemosensor RDP-1 based on a rhodamine tri methoxy benzaldehyde conjugate was synthesized, which showed high selectivity and sensitivity towards recognition of Pb2+ in aqueous media over other metal ions and also color changes from colorless to pink, allowing colorimetric detection of Pb2+ by the naked eye. The sensitivity of probe RDP-1 towards Pb2+ was demonstrated in living cells, and can be used for selective imaging of Pb2+ in living cells.

Aptamer-based label-free detection of PDGF using ruthenium (II) complex as luminescent probe

In this work we report a simple, cost-effective, and label-free detection method, consisting of a platelet-derived growth factor (PDGF) binding aptamer and hydrophobic Ru(II) complex as a sensor system for PDGF. The binding of PDGF with the aptamer results in the weakening of the aptamer – Ru(II) complex, monitored by luminescence signal. A substantial enhancement in the luminescence intensity of Ru(II) complex is observed in the presence of aptamer due to the hydrophobic interaction. Upon addition of PDGF, the lumi nescence intensity is decreased, due to the stronger interaction between the aptamer and PDGF resulting in the displacement of Ru(II) complex to the aqueous solution. Our assay can detect a target specifically in a complex medium such as the mixture of proteins, at a concentration of 0.8 pM.

S.NO NAME OF THE SCHOLAR SUPERVISOR NAME MODE OF RESEARCH AREA OF SPECIALIZATION STATUS
1 S. Omprakash Dr. S. Singaravadivel Full – Time Curcumin – Loaded Nano Carriers On-Going
2 R. Senthamil Selvan Dr. S. Singaravadivel Part – Time Synthesis and Characterisation of Naturally derived Carbon nanomaterials and their applications in Cell-Imaging On-Going

Awards

  • Visiting fellow to Prof. Kuang – Lieh Lu lab, Institute of Chemistry, Academia Sinica, Taipei, Taiwan Nov, 2010 – Jan 2011.
  • CSIR –JRF joint Lecturer Ship (2010).
  • CSIR-SRF (2010-2012)
  • National Science Council Post Doctoral Fellowship Taiwan (2012-2013).
S.NO NAME OF THE FACULTY DEPARTMENT TITLE OF PROJECT/CONFERENCE/

SEMINAR/WORKSHOP

FUNDING AGENCY  

STATUS (Sent/Sanctioned /  Rejected)

1. Dr. S. Singaravadivel CHEMISTRY “Functionalised Poly diacetylenes as multi modal sensors” DST – ECR Sanctioned

(2017-2020)

30.84 Lakhs

Publication Details (2018-2019)
S.No Name of the Author Title of the paper Name of the Journal ISSN No Web Link
1. S. Singaravadivel A Fluorescent Turn-On Carbazole-Rhodanine Based Sensor for Detection of Ag+ Ions and Application in Ag+ Ions Imaging in Cancer Cells Journal of fluorescence 1573-4994 http://link-springer-com-443.webvpn.jxutcm.edu.cn/article/10.1007%2Fs10895-018-2312-6
2. S. Singaravadivel Anthracene-Based Highly Selective and Sensitive Fluorescent “Turn-on” Chemodosimeter for Hg2+ ACS omega 2470-1343 https://pubs.acs.org/doi/10.1021/acsomega.8b01142
3. S. Singaravadivel Pineapple Peel-Derived Carbon Dots: Applications as Sensor, Molecular Keypad Lock, and Memory Device ACS omega 2470-1343 https://pubs.acs.org/doi/10.1021/acsomega.8b01146
4. S. Singaravadivel Rhodamine-benzothiazole conjugate as an efficient multimodal sensor for Hg2+ ions and its applications of imaging in living cells New Journal of Chemistry 1144-0546 https://pubs.rsc.org/en/content/articlelanding/2018/nj/c8nj01736k/unauth#!divAbstract
Publication Details (2017-2018)
5. S. Singaravadivel Chemically diverse small molecule fluorescent chemosensors for copper ion Coordination Chemistry Reviews 1873-3840 https://www.sciencedirect.com/science/article/abs/pii/S0010854517306537
6. S. Singaravadivel Carbazole–azine based fluorescence ‘off–on’sensor for selective detection of Cu2+ and its live cell imaging Luminescence 1522-7243 https://onlinelibrary.wiley.com/doi/abs/10.1002/bio.3332
7. S. Singaravadivel Highly fluorescent carbon dots from Pseudo-stem of banana plant: applications as nanosensor and bio-imaging agents Sensors and Actuators B: Chemical 0925-4005 https://www.sciencedirect.com/science/article/pii/S0925400517311085
8. S. Singaravadivel Rhodamine‐Based Fluorescent Turn‐On Probe for Facile Sensing and Imaging of ATP in Mitochondria Chemistry Select 2365-6549 https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201701149
9. S. Singaravadivel Rhodamine based effective chemosensor for Chromium (III) and their application in live cell imaging Sensors and Actuators B: Chemical 0925-4005 https://www.sciencedirect.com/science/article/pii/S0925400517303799
Publication Details (2016-2017)
10. S. Singaravadivel Rhodamine Diaminomaleonitrile Conjugate as a Novel Colorimetric Fluorescent Sensor for Recognition of Cd2+ Ion Journal of fluorescence 1573-4994 https://link.springer.com/article/10.1007/s10895-017-2046-x
11. S. Singaravadivel Phenothiazine-diaminomalenonitrile based Colorimetric and Fluorescence “Turn-off-on” Sensing of Hg2+ and S2− Sensors and Actuators B: Chemical 0925-4005 https://www.sciencedirect.com/science/article/pii/S092540051630689X
12. S. Singaravadivel Fluorescence “on–off–on” chemosensor for selective detection of Hg2+ and S2−: application to bioimaging in living cells RSC Advances 2046-2069 http://dx.doi.org/10.1039/C5RA26281J
Publication Details (2015-2016)
13. S. Singaravadivel A rhodamine based “turn-on” fluorescent probe for Pb (II) and live cell imaging RSC Advances 2046-2069 http://dx.doi.org/10.1039/C5RA20482H
14. S. Singaravadivel Sensing and inhibition of amyloid-β based on the simple luminescent aptamer–ruthenium complex system Talanta 0039-9140 https://www.sciencedirect.com/science/article/pii/S0039914014009126
15. S. Singaravadivel Phenothiazine based sensor for naked-eye detection and bioimaging of Hg (II) and F− ions RSC Advances 2046-2069 http://dx.doi.org/10.1039/C5RA19341A
Publication Details (2014-2015)
16. S. Singaravadivel A selective, long-lived deep-red emissive ruthenium (II) polypyridine complexes for the detection of BSA Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 1386-1425 https://www.sciencedirect.com/science/article/pii/S1386142514006337
Publication Details (2013-2014)
17. S. Singaravadivel Sensitized Near-Infrared Luminescence From NdIII, YbIII and ErIII Complexes by Energy-Transfer From Ruthenium 1,3-Bis([1,10]Phenanthroline-[5,6-d]-Imidazol-2 -yl)Benzene Journal of fluorescence 1573-4994 https://link.springer.com/article/10.1007/s10895-013-1247-1
18. S. Singaravadivel Sensitized near-infrared luminescence of lanthanide complexes by energy transfer from a ruthenium antenna Polyhedron 0277-5387 https://www.sciencedirect.com/science/article/pii/S0277538713003859
19. S. Singaravadivel Sensitized near-infrared luminescence of NdIII, YbIII and ErIII complexes by energy transfer from a ruthenium antenna Journal of Organometallic Chemistry 0022-328X https://www.sciencedirect.com/science/article/pii/S0022328X13002611
Publication Details (2012-2013)
20. S. Singaravadivel Aptamer-based label-free detection of PDGF using ruthenium (II) complex as luminescent probe Analytical and bioanalytical chemistry 1618-2642 https://link.springer.com/article/10.1007/s00216-013-7118-4
21. S. Singaravadivel Sensitized near-infrared luminescence of lanthanide complexes by energy transfer from rhenium(I) complexes bridged by bis(benzimidazole) and phenanthrolino-5,6:5′,6′-pyrazine ligands Inorganica Chimica Acta 0020-1693 https://www.sciencedirect.com/science/article/pii/S0020169313000534

Others

Memberships

  • ISRAP, Life Time Member.
  • CRSI, Life Time Member.

 Seminars and Conferences

  1. Presented a paper in National Seminar on Recent Trends in Chemistry organized by Department of Chemistry, Jayaraj Annapackiam College For women (Autonomous) Periyakulam on 9-10th August, 2007.
  2. Presented poster in NSRP organized by department of physics Kuman University, Nainital on March 12-14th 2009.
  3. Presented poster in SABIC 2009 organized by department of chemistry, TIFR Mumbai on 4-7th November, 2009.
  4. Presented poster in CRSI symposium held at IICT Hyderabad on 5-7th February, 2010.
  5. Presented poster in RAINC 2010, in Madurai Kamaraj University on 29-30th March 2010.
  6. Presented poster in 3rd APSRC-TSRP 2010, in Treasure Island, Lonavala on 14-17th September 2010.

Gallery

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