Dr.S.Singaravadivel

Overview

Dr. S. Singaravadivel is an Assistant Professor at SSMIET in chemistry department. He is working as a faculty in SSMIET for the past 3 Years 2 Months. His research is mainly focused on development of probes for sensing biomoelcules, Heavy metal ions, anions and explosives.

Contact:  vesp1984@gmail.com    +91-9942698726

Education

  • PDF (Chemistry), Institute of Chemistry, Academia Sinica, Taipei, Taiwan, 2012-2013.
  • Ph.D (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2012.
  • M.Phil (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2007.
  • M.Sc (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2006.
  • B.Sc (Chemistry), Madurai Kamaraj University, Madurai, Tamil Nadu, 2004.

Research

Singaram’s area of research is broadly focused on development of Organic, Polymer and NIR probes for sensing biomolecules, Heavy metal ions, anions and explosives with their practical applications in real time and in-vivo and in-vitro Cell-imaging.

Phenothiazine based sensor for naked-eye detection and bioimaging of Hg (II) and F− ions

This work is mainly concentrated on the design and development of new phenothiazine-based fluorescent probes, which display a selective fluorescence response to mercury and fluoride ions, were described. The probe is the first example that facilitates the detection of Hg2+ at nanomolar concentrations.  The sensitivity of probe P-1 to Hg2+ and F was demonstrated in living cells, and cell toxicity assays revealed that probe P-1 can be used for selective imaging of Hg2+ and F in living cells.

A rhodamine based “turn-on” fluorescent probe for Pb (ii) and live cell imaging

This work is mainly focused on a novel “turn-on” fluorescent chemosensor RDP-1 based on a rhodamine tri methoxy benzaldehyde conjugate was synthesized, which showed high selectivity and sensitivity towards recognition of Pb2+ in aqueous media over other metal ions and also color changes from colorless to pink, allowing colorimetric detection of Pb2+ by the naked eye. The sensitivity of probe RDP-1 towards Pb2+ was demonstrated in living cells, and can be used for selective imaging of Pb2+ in living cells.

Aptamer-based label-free detection of PDGF using ruthenium (II) complex as luminescent probe

In this work we report a simple, cost-effective, and label-free detection method, consisting of a platelet-derived growth factor (PDGF) binding aptamer and hydrophobic Ru(II) complex as a sensor system for PDGF. The binding of PDGF with the aptamer results in the weakening of the aptamer – Ru(II) complex, monitored by luminescence signal. A substantial enhancement in the luminescence intensity of Ru(II) complex is observed in the presence of aptamer due to the hydrophobic interaction. Upon addition of PDGF, the lumi nescence intensity is decreased, due to the stronger interaction between the aptamer and PDGF resulting in the displacement of Ru(II) complex to the aqueous solution. Our assay can detect a target specifically in a complex medium such as the mixture of proteins, at a concentration of 0.8 pM.

Awards

  • Visiting fellow to Prof. Kuang – Lieh Lu lab, Institute of Chemistry, Academia Sinica, Taipei, Taiwan Nov, 2010 – Jan 2011.
  • CSIR –JRF joint Lecturer Ship (2010).
  • CSIR-SRF (2010-2012)
  • National Science Council Post Doctoral Fellowship Taiwan (2012-2013).

Publications

Below is a list of my publications. Copyright and all rights therein are retained by authors or by other copyright holders.

  1. Muthu Vengaian, C. Denzil Britto, K. Sekar, G. Sivaraman, S. Singaravadivel, Phenothiazine-diaminomalenonitrile based Colorimetric and Fluorescence “Turn-off-on” Sensing of Hg2+ and S2+, Sensors and Actuators B: Chemical, 235, 2016, 232-240. (Impact Factor : 4.758)
  2. Muthu Vengaian, C. Denzil Britto, K. Sekar, G. Sivaraman, S. Singaravadivel, “Fluorescence “on-off-on” chemosensor for selective detection of Hg2+ and S2-: application to bioimaging in living cells” RSC Advances, 667, 2016, 668-7673. (Impact Factor : 3.289)
  3. Sunnapu, N.G. Kotla, B. Maddiboyina, S. Singaravadivel, G. Sivaraman, “A rhodamine based “turn-on” fluorescent probe for Pb (II) and live cell imaging” RSC Advances, 6, 2016, 656-660. (Impact Factor : 3.289)
  4. Muthu Vengaian, C. Denzil Britto, G. Sivaraman, K. Sekar, S. Singaravadivel, “Phenothiazine based sensor for naked-eye detection and bioimaging of Hg (II) and F− ions” RSC Advances, 5, 2015, 94903-94908. (Impact Factor : 3.289)
  5. Babu, P. Muthu Mareeswaran, V. Sathish, S. Singaravadivel, S Rajagopal, “Sensing and inhibition of amyloid-β based on the simple luminescent aptamer–ruthenium complex system” Talanta, 134, 2015, 348-353. (Impact Factor : 4.035)
  6. Babu, S. Singaravadivel, P. Muthu Mareeswaran, J. Bhuvaneswari, S. Rajagopal, “A Selective, Long-Lived Deep-Red Emissive Ruthenium (II) Polypyridine Complexes for the Detection of BSA” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 130, 2014, 553-560. (Impact Factor : 2.653)
  7. Singaravadivel, M. Velayudham, P. Muthu Mareeswaran, K.-L. Lu and S. Rajagopal, “Sensitized near-infrared luminescence from NdIII, YbIII and ErIII complexes by energy-transfer from Ru(II)-bpibH2 (1,4-bis(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene) complex” Journal of Fluorescence, 23, 2013, 1167-1172. (Impact Factor : 1.601)
  8. Babu, S. Singaravadivel, P. Manojkumar, S. Krishnasamy, G. Gnana kumar, S. Rajagopal, “Aptamer-based label-free detection of PDGF using ruthenium(II) complex as luminescent probe” Anal Bioanal Chem, 405, 2013, 6891–6895. (Impact Factor : 3.125)
  9. Singaravadivel, M. Velayudham, E. Babu, K.-L. Lu and S. Rajagopal, “Sensitized Near-Infrared Luminescence from Ln(III) Centers by Energy Transfer from Ru(II)-tpphz (tetrapyrido[3, 2-a:2′, 3”-c:3”, 2”-h:2”’, 3”’-j] phenazine) Metal Center”, Polyhedron, 60, 2013, 54-58. (Impact Factor : 2.108)
  10. Singaravadivel, M. Velayudham, E. Babu, K.-L. Lu and S. Rajagopal, “Sensitized near-infrared luminescence from NdIII, YbIII and ErIII complexes by energy-transfer from ruthenium bibenzimidazole”, Journal of Organometalic Chemistry, 738, 2013, 49-54. (Impact Factor : 2.336)
  11. Singaravadivel, M. Velayudham, E. Babu, K.-L. Lu and S. RajagopalSensitized near infrared luminescence of lanthanide complexes by energy transfer from rhenium(I) complexes bridged by bis(benzimidazole) and phenanthrolino-5,6:5′,6′-pyrazine ligands”, Inorganica Chimica Acta, 400, 2013, 215-221. (Impact Factor : 1.918)
  12. Velayudham, S. Singaravadivel, S. Rajagopal, P. Ramamurthy, “Synthesis, characterization and photophysics of alkyne bridged bimetallic rhenium(I) and ruthenium (II) complexes”, Journal of Organometallic Chemistry, 694, 2013, 4076-4083. (Impact Factor : 2.336)

Others

Memberships

  • ISRAP, Life Time Member.
  • CRSI, Life Time Member.

 Seminars and Conferences

  1. Presented a paper in National Seminar on Recent Trends in Chemistry organized by Department of Chemistry, Jayaraj Annapackiam College For women (Autonomous) Periyakulam on 9-10th August, 2007.
  2. Presented poster in NSRP organized by department of physics Kuman University, Nainital on March 12-14th 2009.
  3. Presented poster in SABIC 2009 organized by department of chemistry, TIFR Mumbai on 4-7th November, 2009.
  4. Presented poster in CRSI symposium held at IICT Hyderabad on 5-7th February, 2010.
  5. Presented poster in RAINC 2010, in Madurai Kamaraj University on 29-30th March 2010.
  6. Presented poster in 3rd APSRC-TSRP 2010, in Treasure Island, Lonavala on 14-17th September 2010.

Gallery

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